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While traditionally recognized for generating adenosine triphosphate (ATP) through oxidative phosphorylation, mitochondria are also critical for calcium buffering, regulation of reactive oxygen species (ROS), and apoptosis, all of which are essential during neurodevelopment 7,8,9

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A patient with favorable GLP1R variants may see robust appetite suppression at lower doses, while another with FTO rs9939609 variant patterns might benefit from earlier dose escalation