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In total, ~15-20% of patients with AA and 2-6% of patients with PNH were found to to develop secondary MDS/AML by 10 years of follow-up

systemic = whole-body tissue effects)

[43]: Histological evaluation of stomach injuries Hematoxylin and eosin staining For each rat, the stomach wall specimens were put in 10% buffered formalin for fixation, processed in machine of tissue-processing (Leica, Germany) and paraffin-embedded

Interest peaked in 2022-2024 when high-profile individuals such as Elon Musk and Oprah Winfrey posted on their social media accounts that they were taking this medication for weight management, leading to surging global demand and widespread supply shortages that continue to affect Singapore