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In T2DM, therapies targeting systemic comorbidities, such as SGLT-2 inhibitors and GLP-1 receptor agonists, are critical

The Klotho protein is crucial in the functionality of renal tubular epithelial cells, and mice deficient in Klotho exhibit traits associated with aging ( Ink4a pathway can exacerbate cellular senescence, leading to G2/M phase cell cycle arrest

Cell Signaling Technology, clone 4872 S) or anti-calreticulin antibody (0.406 g/mL, 1:400 dilution in antibody dilution buffer, Cell Signaling Technology

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