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Discuss your complete medical history , particularly: Personal or family history of thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis or severe gastrointestinal disease Kidney function status Other endocrine conditions, including diabetes complications Your doctor may coordinate care with specialists such as an endocrinologist, particularly if you have complex thyroid disease or difficult-to-control diabetes

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Losing muscle can lower your resting metabolic rate, making it harder to keep the weight off in the long term