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Yilmaz, G., Srer, H., Inan, L

This does not make it the most effective, which remains debated, but it does make it among the best characterized for safety

IGF-1 upregulates PD-L1 via the IGF-1R/AKT/ERK signaling cascade Contrary to its repressive effects on APM genes, IGF-1 significantly induced CD274 (PD-L1) mRNA and surface protein expression in DU145 cells

Further functional studies with replication of the work in other ethnic populations are recommended to support the ethnic-specific genetic variations