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1.2 Safety considerations and the limits of the GLP-1 analogy The success of GLP-1 receptor agonists should not obscure legitimate safety considerations associated with chronic peptide therapy

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In summary, the composition of BAs in T2DM patients requires further analysis through additional clinical studies that consider relevant factors such as age, sex, geographic location, the use of bile acid drugs (e.g., metformin), and metabolic surgery [19, 35, 36]

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