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A modest, controlled increase in GH can create a system-wide anabolic and regenerative state that supports the healing of all tissues, including cartilage and connective tissues found in the spine

27 , e15055 (2024)

At the same time, thrombin promotes M1 macrophage polarization, enhancing their capacity to phagocytose MSU crystals and intensifying inflammatory mediator release, which contributes to the early inflammatory framework necessary for tophus formation