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[8] That is the design thesis behind retatrutides unusually large weight-loss figures and also behind its distinctive side-effect signal, discussed below

Gastric distension from large meals compounds the delayed emptying caused by semaglutide

It reports roughly 20 to 30 percent of semaglutide users describing constipation in clinical trials, which is why it treats gastrointestinal symptom management as a normal part of starting treatment rather than an unusual complication