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Although a single nodule can have a higher risk of being malignant than one of many nodules in an enlarged thyroid gland, the overall risk is about equal due to the risk attached to each individual nodule in a large gland

Experimental approaches: including target screening, cellular assays (Shah et al., 2016), animal models (Ridges et al., 2012), and clinical studies (Zhu et al., 2014)

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2.1 Criteria for identifying underexplored peptide systems To operationalize this definition, peptidereceptor systems considered underexplored in this review meet several criteria