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Galuppo et al., 2013), and reduced motor impairments (Galuppo et al., 2013)

Initiation should follow a 'start low, go slow' approach with gradual dose titration, and renal function should be assessed before starting treatment

Its molecular target is nicotinamide N-methyltransferase (NNMT), a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, consuming SAM and releasing S-adenosylhomocysteine

Blanks were acquired after each triplicate measure