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At the end of the experiment, mice were anesthetized with Avertin (300 mg/kg body weight) after 4 h of fasting
Research has shown that phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first reaction in the serine synthesis pathway, was highly upregulated in metastatic breast cancer and was correlated to short patient survival times [135, 136]
252 DHEA and DHEA-S have androgenic (male hormone) properties and are also used to synthesize estrogens (estradiol and estrone) and other androgens (androstenedione, testosterone, dihydrotestosterone) in the adrenal glands and other tissues
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