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[PMC free article: PMC5878302] [PubMed: 29592996] [CrossRef] 219

Baseline copper status individuals with Wilsons disease or copper overload conditions should not be subjects in interventional studies involving exogenous copper, even in chelated form

The logical next step is to translate these parameter-dependent effects into optimized protocols for direct intra-articular light delivery in KOA, where precise control over energy delivery is paramount

Compounded drugs are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality