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Using the human hepatoma cell line HuH7 as a model, Leung et al

Ruvolo PP, Zhou L, Watt JC, Ruvolo VR, Burks JK, Jiffar T, Kornblau S, Konopleva M, Andreeff M

However, as a precaution, these drugs are not recommended for individuals with a personal or family history of medullary thyroid carcinoma or MEN 2

It also raises the possibility that FSP1 inhibitors may disrupt multiple parallel antioxidant systems, potentially enhancing therapeutic efficacy in oxidative stress-dependent pathologies, including cancer and degenerative diseases