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[] Furthermore, recent evidence uncovered the previously depreciated function of GIP in the brain and supports the physiological and pharmacological relevance of GIP in weight loss and obesity

The Washington Post

Beneficial gut microbiota, including Bifidobacterium , Lactobacillaceae-associated taxa , Faecalibacterium , Roseburia , and other anaerobic fermenters, contribute directly or indirectly to SCFA production 158

In the gastrointestinal tract, GLP-1R reduces gastric acid secretion, slows gastrointestinal motility, delays gastric emptying, and increases satiety, thereby aiding weight management