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neuroinflammation further impairs neuronal mitochondrial function and synaptic plasticity, exacerbating central energy deficiency and interoceptive dysregulation
Blood 58(Suppl 1):133a, 1981
Oncogene 26(28):4148-4157, 2007
Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA
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