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heart failure risk - An FDA warning (4/6/16) was added to saxagliptin regarding an increased risk of heart failure observed in two randomized trials (3.5% risk vs 2.8% for those taking placebo)

Ibutilide (class III) and amiodarone are second-line options, but their effectiveness is less established DC cardioversion may still be required if drug therapy fails The re-entry circuit involves the AV node why cant we use AV nodal blocking agents

The reduction of food intake with amylin is not accompanied by the expected concomitant decrease in energy expenditure through actions at the sympathetic nervous system

If you want a quick refresher on how semaglutide works, see our overview here