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Iepsen EW, Lundgren JR, Hartmann B et al (2015) GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women

The regulatory gap in the Retatrutide vs Tirzepatide comparison represents both a risk and an opportunity for researchers: Retatrutide offers access to cutting-edge triple agonist biology before commercial availability, but without the safety certainty that FDA approval provides

Moreover, a 2020 study revealed that GLP-1s were associated with an increased chance of intestinal obstructions compared to other types of diabetes management drugs

Neither approach is right for everyone