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In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions

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During the program, the patients used around a third of the amount of semaglutide that is used on the standard treatment schedule (36.1% of the suggested cumulative dose at week 64 and 34.3% at week 76)