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Proc Natl Acad Sci USA 104, 1394213947 (2007)

Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone

Dose 2 g/day is more effective for decreasing insulin level, but we did not find a significant non-linear relationship between the duration of the intervention (weeks) (coefficients = 0.74, p = 0.177) and changes in insulin (Figures 4B, 5B)

Stay hydrated by drinking at least 8 glasses (or 2 liters) of water per day