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Implementation Statistical tests, transomic network analysis, fluxes simulation, and analysis were performed using MATLAB 2021a (The Mathworks Inc.)

The elevation of extracellular glu levels suppresses system Xc-, leading to the initiation of ferroptosis ( 3.1.1 System Xc- System Xc-is consisted of SLC7A11 (catalytic subunit) and solute carrier family 3 member 2 (SLC3A2, regulatory subunit) (Sato et al., 1999)