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Importantly, brain endothelial cells are known to gain their specialized BBB functions through interactions with other cells of NVU such as pericytes, astrocytes, and neurons (Canfield et al., 2019), which is crucial for the development, regulation, maintenance of the neural barriers (Daneman et al., 2010a, b)
Therefore, we commonly regard the expression of PGC1 , NRF1 , TFAM , and mitochondrial-related genes, as well as mtDNA copy number as the markers for mitochondrial biogenesis
(134) evaluated a six-week intervention involving combined supplementation of fish oil (1.7 g EPA + DHA/day), plant sterol-enriched chocolate (2.2 g/day), and green tea (~170.8 mg/day) in 53 statin-intolerant type 2 diabetes patients
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