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In summary, the implication of IGF-1 in glucose and lipid metabolism and its derangements when the GH/insulin/IGF-1 axis balance fails is well documented

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doi: 10.1016/S1087-0792(98)90020-X 45 HardelandRPoeggelerB

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Studies suggest that approximately 60% of hepatic fat derives from adipose tissue lipolysis, 25% from DNL, and 15% from dietary sources [7]

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The ineffectiveness of 3-adrenreceptor activation to induce significant and sustained lipolysis in humans may be explained by the fact that human WAT expresses minimal levels of 3-adrenoreceptors

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