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Protocol 2: Twice Daily (Split Dose) When: First dose immediately upon waking (fasted)

Novelty of the Blend: For novel blends or those with less existing research, a more conservative cycling approach (shorter on-cycles, longer off-cycles) might be prudent until more data is accumulated

Canning reduced folate by up to 40% in table beets with increasing processing time and temperature, while it did not cause any significant folate amount changes in green beans, compared to unprocessed vegetables 467

Generally, weight loss of greater than 24% of initial body weight and at a rate greater than 1.5 kg (about 3.3 pounds) per week has been identified as a risk factor for gallstones, but the risk may be mitigated by controlling the rate of weight loss, reducing the length of the overnight fast, and keeping a small amount of fat (at least 7 grams per day) in the diet to improve gallbladder motility (Erlinger 2000)