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It belongs to a novel class of drugs known as triple agonists , meaning it simultaneously activates three hormone receptors: GLP-1 (glucagon-like peptide-1) which reduces appetite and slows gastric emptying [9] [10] GIP (glucose-dependent insulinotropic polypeptide) which may enhance insulin secretion and has been suggested in early studies to support fat metabolism Glucagon receptor which may increase energy expenditure and has been proposed to support fat breakdown in the liver, based on early pharmacological data [11] [12] This triple mechanism distinguishes retatrutide from existing approved medicines such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GLP-1/GIP agonist)

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Most gastrointestinal side effects such as bloating and gas are mild and self-limiting, typically resolving within days to weeks as the gut microbiome adjusts to the introduced bacterial strains

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