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Testing revealed that the intra-assay coefficient of variation for the PAI-1 antigen ranged from 3.6-16.9% and the inter-assay coefficient of variation was 4.3-6.8%

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Researchers should determine suitability based on the requirements of their individual study protocols

If were not just talking about age-related changes - perhaps youve lost weight and thats caused your cheeks to prematurely deflate, or you want to tweak your natural cheeks and change their contour - in that case, fillers can be used as early as age 16 (though usually in minors theyre reserved for reconstructive work)