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A process that takes 618 months depending on the substance and duration of use

Combined deletion of Mfn1/2 in -cells reduces mtDNA content, impairs mitochondrial morphology and network, and compromises respiratory function, eventually resulting in severe glucose intolerance (Sidarala et al., 2022)

After three months, participants shed an average of 16.8 lbs (7.6 kg) and saw their BMI drop by 3.1 points