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The expression mechanisms of PD-L1 in tumors may involve signaling pathways within the TME, such as IFN--induced PD-L1 expression, or activation of oncogenic signaling pathways, including PI3K/AKT and MAPK, to promote PD-L1 expression (90, 91)

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Tirzepatide has been evaluated for long-term use in clinical trials, with most users experiencing positive results without significant safety concerns

Patent expirations, generics competition, and a global surge in metabolic drug development could dramatically increase the number of trials targeting obesity and metabolic disease