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Studies have shown that N-terminal modifications of Incretins - specifically changing the second amino acid in the GLP-1 and GIP molecules from Ala to Gly or other amino acid can reduce the rate of DPP-4 inactivation of these peptides without impacting their ability to bind to their cognate receptors (Green and Flatt, 2007)

Ipamorelin is designed to primarily stimulate growth hormone release without significantly impacting other hormones like cortisol or prolactin

MITF upregulates tyrosinase, the rate-limiting enzyme that converts L-tyrosine to L-DOPA, the precursor to eumelanin and pheomelanin

Notably, we observed distinct metabolic signatures distinguishing focal from generalized seizures.To our knowledge, this is the first comprehensive serum metabolomics study using NMR to evaluate both basal and post-seizure states in epilepsy