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Much of the research in recent years has focused on animal models and in vitro studies, and data on their effects on the human immune system are limited

The activation of macrophages and astrocytes leads to an increase in proinflammatory cytokines, chemokines, and endothelial adhesion molecules

Functionally, MTHFR bridges one-carbon metabolism with the epigenome by generating 5-methyl-THF for methionine remethylation and SAM synthesis, thereby determining the methyl-group supply available for DNA and histone methyltransferases

The body's innate method of dealing with this sun damage are repair mechanisms that make use of antioxidants