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The gradual titration schedule starting at low doses and increasing incrementally over several weeks is specifically designed to minimise gastrointestinal effects and improve tolerability

The use of triptans, ergotamine-dihydroergotamine, or combination analgesics should be limited to nine or fewer days a month on average, butalbital-containing analgesics should be used sparingly and dosing limited to three or fewer days a month, and NSAIDs to 14 or fewer days a month to prevent MAH

Image Credit: Vicente Fernandez Garcia / Shutterstock A recent review published in the Canadian Journal of Physiology and Pharmacology highlights growing evidence that the gut microbiota may influence the therapeutic effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

SNAC (salcaprozate sodium) 3mg