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Finally, agonist-induced internalization and recycling of a green fluorescent protein (GFP)-tagged human GLP-1R construct expressed in HEK 293 cells was visualized using confocal microscopy (Fig

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The adverse events associated with GLP-1RA are predominantly GI, particularly nausea, vomiting, and diarrhea, and occur in 1050% of patients in clinical trials (Table 2) ( Pancreatitis and Pancreatic Cancer Since the introduction of GLP-1RA and DPP-4 inhibitors there has been some concern regarding the potential increase in pancreatitis and possibly pancreatic cancer with the incretin class of medications

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