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HA has been shown to modulate ocular surface inflammation through interactions with CD44 and other cell-surface receptors, thereby influencing leukocyte trafficking and reducing the expression of pro-inflammatory cytokines and chemokines ( One of the most intriguingly and seemingly counterintuitive findings of our study was the posttreatment surge in tearfluid cytokines (IFN-2, IFN-, TNF-, IL-6, IL-23 and IL-33) that accompanied clinical improvements in tearfilm stability and corneal integrity

Mortality rates The following tables estimate the potential cumulative and annualized population improvements for mortality over the next 20 years

All patients provided their informed consent before the study and the protocol was approved by the Ethical Review Committee of Kursk State Medical University