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Studies in thyrotoxic rats suggest that the oxidative stress may be involved in the pathogenesis of thyrotoxic myopathy and cardiomyopathy (26) and in vitro studies have shown that exposure of thyroid cell to H 2 O 2 , particularly when made selenium-deficient, induces DNA double strand breaks, apoptosis, necrosis and mutagenesis (24)

4) And (3) post-treatment: and after cyclization is finished, filtering the mixture by using a microporous filter membrane to obtain a crude Cagrilintide product