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Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine

From experimental data of kinetic measurements of BRET, following vehicle and baseline corrections, quantification of induced responses from individual peptide concentrations was determined by calculating the net area under curve from the 10 min response (AUC 0-10min) ) in GraphPad Prism version 9.0.1 (GraphPad Software Inc., San Diego, CA)

Muscle discomfort during weight loss treatment typically results from lifestyle changes rather than the medication itself, with most GI side effects improving within the first month

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