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Because SCD is hallmarked by an underlying chronic inflammatory status, which is partly driven by proinflammatory M1 macrophages [51], heme scavenging or modulation, as well as the potential therapeutic targeting of mitochondrial biogenesis, might significantly ameliorate tissue damage associated with SCD pathophysiology [52]

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The good news is that there are multiple evidence-based treatment options, and many patients improve with the right clinician-guided plan

They also recommend it for Turner syndrome and Prader-Willi syndrome