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10.1038/s41569-020-0403-y 20

FIGURE 2 3 The activation mechanism of eryptosis in renal anemia In the uremic milieu of CKD, a constellation of factorsincluding uremic toxin accumulation, chronic inflammation, oxidative stress, and hypoxiaconverge to induce cellular damage signals that promote eryptosis, the programmed death of erythrocytes

M.de Abreu e LimaF.SoriaC.WillmitzerL.FernieA

Moreover, partial meniscectomy, though considered less invasive, still results in long-term joint degeneration, especially when combined with factors such as limb malalignment or ACL deficiency (Zhang H