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& Rai, P

The peptide stimulates expression of early growth response 1 (EGR-1) gene, which regulates cytokine and growth factor generation along with early extracellular matrix formation, while simultaneously inducing its repressor NAB2 to prevent excessive angiogenic signaling

The latter are coated with enzyme-sensitive linkers or coatings that are responsive to MMPs and disintegrate to release the entrapped antioxidants at the tumour site

Although some researchers point out that the overall body of literature on safety is lacking, available studies indicate that with glutathione IV therapy, side effects are unlikely