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Biochem Biophys Res Commun 298:779784 Maida A, Lamont BJ, Cao X, Drucker DJ (2011) Metformin regulates the incretin receptor axis via a peroxisome proliferator-activated receptor alpha-dependent pathway in mice

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nevertheless, patients transitioned to liraglutide sustained efficacy irrespective of antibody status (Garber 2011)

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The glucagon receptor provides a third pathway unaffected by any theoretical GLP-1 or GIP desensitization

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