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A systematic review analyzing multiple clinical trials confirmed that oral glutathione at doses of 250-500mg showed a significant reduction in melanin index compared to placebo over 8-12 weeks

Glutathione exists in two primary states within the cell: Reduced glutathione (GSH): The active, antioxidant form Oxidized glutathione (GSSG): The spent form, converted back to GSH by the enzyme glutathione reductase using NADPH Under healthy physiological conditions, more than 98% of cellular glutathione exists in the reduced (active) form

These include redness, swelling, tenderness, itching, bruising, and occasionally a small lump or bump under the skin that may persist for several days

Oral glutathione supplements may, from time to time, cause nausea, bloating, diarrhea, or stomach discomfort, especially when taken on an empty stomach or when taken in excess of the recommended dose