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Ozempic may exacerbate preexisting kidney issues

Most of the outcomes assessed in the included studies were relevant to clinical practice and based on clinical outcomes such as change in A1C, body weight, lipid profile, blood pressure, mortality, and diabetes-related morbidity

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Additionally, repeated freeze-thaw cycles are particularly damaging to metal-peptide complexes because the copper(II) ion can catalyze oxidative damage to the histidine imidazole ring during the transient concentration spikes that occur at ice-liquid interfaces