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When to call your care team Call your clinic or infusion center if you notice any of the following: Blisters, bruising, dark color, or peeling of the skin at the IV site Fluid, blood, or pus leaking from the IV site Numb, tight, or cool feeling at the IV site Redness, pain, or swelling at the IV site that gets worse or fails to get better in 24 hours Fever of 100.4F (38C) or higher, or as directed by your care team Key points about IV infiltration IV infiltration happens when medicines or other fluid given by an IV catheter leaks out into the surrounding tissue