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References consulted in writing this blog post: Jaime P Almandoz 1 , Thomas A Wadden 2 , Colleen Tewksbury 3 , Caroline M Apovian 4 , Angela Fitch 5 , Jamy D Ard 6 , Zhaoping Li 7 , Jesse Richards 8 , W Scott Butsch 9 , Irina Jouravskaya 10 , Kadie S Vanderman 11 , Lisa M Neff 10

Typical patterns include: Rapid initial loss (first 4-6 weeks), much of which is water and glycogen Steady loss during mid-protocol (weeks 6-24) Plateaus lasting 1-3 weeks that resolve spontaneously Slower deceleration as you approach new equilibrium weight If you hit a plateau on tirzepatide that persists beyond 4-6 weeks at maximum dose, the tirzepatide troubleshooting guide covers the most common causes and solutions