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The mast cells mainly reside in connective tissue, in which the extracellular matrix is made of proteins that hold the tissue together

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On top of exacerbating high blood sugar, this metabolic impairment puts people in danger for complications such as diabetic neuropathy, which at its core involves disturbances in glucose and fatty acid metabolism that lead to abnormal structure and function of peripheral nerves, predisposing them to entrapment neuropathies and irreversible neuronal damage ( Figure 1 Emerging evidence suggests that nutrient metabolism contributes to the pathogenesis of diabetic complications, particularly in organs that are sensitive to injury, such as the kidney, retina and peripheral nerve

Pierre Fontanillas, Sarah L