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Its evidence base is genuinely strong for a trial-stage product two large Phase 3a randomized controlled trials plus a Phase 1b pharmacology study but it has not received marketing approval from any regulator, and its complete benefitrisk profile is still being evaluated

sEH and the Arachidonic Acid Balance Arachidonic acid metabolism occurs through three main enzyme pathways, and sEH intersects with all of them: COX pathway produces prostaglandins and thromboxanes (inflammatory mediators targeted by NSAIDs) LOX pathway produces leukotrienes (involved in mast cell activation and histamine release) CYP epoxygenase pathway produces EETs (anti-inflammatory, resolved by sEH into inactive DHETs) When COX and LOX pathways are overactive (as in chronic SALI), the CYP epoxygenase/EET pathway serves as a counterbalance

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These factors don't mean Ozempic prevents healing entirely