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Our findings fill this gap by demonstrating that reduced GCLC expression precedes and potentially drives the loss of GSH, leading to a cascade of oxidative stress, mitochondrial dysfunction, and neuronal apoptosis

J Gen Med Clin Pract

In general, L-carnitine is not required for short- and medium-chain fatty acids to enter the mitochondrial matrix as described before, but is necessary for long-chain fatty acids to do so

zIs356 (daf-16p::daf-16a/b::gfp + rol-6) ], and IU679 [ muIs84 (pAD76 sod-3p::GFP + rol-6(su1006)) ], IU827 [ fat-7(wa36) I ], IU740 [ mog-3(q74)/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III)