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For instance, lipopolysaccharide (LPS)-induced inflammation or inflammation owing to protracted ischemiareperfusion injury can generate extensive systemic inflammation (Haruwaka et al., 2019)

Of note, during the 1918 influenza pandemic, more death was observed in the second phase of outbreak 4

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It has been hypothesized that G6PD deficiency confers a selective advantage against malaria, as there is substantial overlap of G6PD deficiency prevalence in regions of historical malaria-endemicity (1), although experimental evidence supporting this malaria protection hypothesis remains mixed (26)