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doi:10.1016/j.cmet.2021.09.001 [Elsevier] Chen P, Poddar R, Tipa EV, et al

Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload

The acute WolffChaikoff effect may be partially explained by the generation of some inhibitory substances, such as intrathyroidal iodolactones, iodoaldehydes, or iodolipids, on thyroid peroxidase activity [35]

These in vivo results align with the in vitro data, consolidating the understanding that GHK-Cu exerts its protective effects in ALI by inhibiting excessive inflammatory responses through its anti-inflammatory and antioxidant properties, mediated by the suppression of NF-B and p38 MAPK signaling pathways [1]