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Disorders in leptin metabolism or the brains response to leptin can result in increased hunger, decreased satiety, and weight gain which are beyond the individuals ability to control with willpower

Mathi SK, Chan Y, Li X, and Wheeler MB

Digestive Issues Women with Lipedema already have higher rates of: IBS Constipation Bloating SIBO (small intestinal bacterial overgrowth) Slow digestion GLP-1s slow gastric emptying even further, which can increase: Constipation Gastroparesis Reflux Nausea If digestive issues are present, they ideally should be addressed before starting GLP-1s