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Collectively, these mechanisms all indicate a reduced and more balanced stress response

Patch-clamp experiments demonstrated how melatonin is able to modulate NMDA receptor activity by the drastic attenuation of their currents in neurons located in the spinal cord dorsal horn 93

Neuroimaging studies have consistently demonstrated reduced D2R availability, reflected by decreased binding potential, in key striatal and extrastriatal regions of obese individuals, supporting an association between obesity, central dopaminergic hypofunction, and dysregulated prolactin homeostasis ( 5 Mechanisms by which obesity may promote hyperprolactinemia We have systematically analyzed the potential mechanisms by which hyperprolactinemia promotes obesity

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