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Semaglutide alone, when titrated to therapeutic doses, produces robust appetite suppression and metabolic benefits for the majority of individuals

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Moreover, in those patients with neurologic signs an electroencephalography (EEG) recording should also be performed to rule out PS, a benign epileptic syndrome, characterized by predominantly autonomic symptoms (including emesis): the availability of EEG recording in pediatric ED might be useful for a prompt and not-cost-consuming diagnosis (133)

While this risk has not been established in humans, semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2